Homemade Hot Pepper Cream for Arthritis & Joint Pain The active component in hot peppers that gives them their heat is called capsaicin, and the hotter the pepper, the higher the level of capsaicin there is. While rubbing something that seems flaming hot onto your sore joints doesn’t initially seem like it would help arthritis, capsaicin cream is commonly sold OTC as a pain reliever. Why? Capsaicin depletes a neurotransmitter called substance P, which is responsible for sending pain signals to

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